Journal article
Applying the ILAE diagnostic criteria for Lennox-Gastaut syndrome in the real-world setting: A multicenter retrospective cohort study
Russell Nightscales, Zhibin Chen, Sarah Barnard, Clarissa Auvrez, Gerard Tao, Shobi Sivathamboo, Caitlin Bennett, Maria Rychkova, Wendyl D'Souza, Samuel F Berkovic, John-Paul Nicolo, Terence J O'Brien, Piero Perucca, Ingrid E Scheffer, Patrick Kwan
Epilepsia Open | Wiley | Published : 2024
DOI: 10.1002/epi4.12894
Abstract
Objective: Lennox-Gastaut syndrome (LGS) is an archetypal developmental and epileptic encephalopathy, for which novel treatments are emerging. Diagnostic criteria for LGS have recently been defined by the International League Against Epilepsy (ILAE). We aimed to apply these criteria in a real-world setting. Methods: We applied ILAE diagnostic criteria to a cohort of patients diagnosed with LGS by epileptologists following inpatient video-EEG monitoring (VEM) at tertiary comprehensive epilepsy centers between 1995 and 2015. We also assessed mortality in this cohort. Results: Sixty patients diagnosed with LGS and had complete records available for review were identified. Among them, 29 (48%) p..
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Funding Acknowledgements
This study was funded by GW pharmaceuticals (now part of Jazz Pharmaceuticals) and supported by Chiesi Australia. The study funders played no role in study design, data collection, or data interpretation.