Journal article
Exploring individual fixel-based white matter abnormalities in epilepsy
R Mito, M Pedersen, H Pardoe, D Parker, RE Smith, J Cameron, IE Scheffer, SF Berkovic, DN Vaughan, GD Jackson
Brain Communications | OXFORD UNIV PRESS | Published : 2024
Abstract
Diffusion MRI has provided insight into the widespread structural connectivity changes that characterize epilepsies. Although syndrome-specific white matter abnormalities have been demonstrated, studies to date have predominantly relied on statistical comparisons between patient and control groups. For diffusion MRI techniques to be of clinical value, they should be able to detect white matter microstructural changes in individual patients. In this study, we apply an individualized approach to a technique known as fixel-based analysis, to examine fibre-tract-specific abnormalities in individuals with epilepsy. We explore the potential clinical value of this individualized fixel-based approac..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
The authors would like to thank all the participants and their families for their involvement in this study. The Florey Institute of Neuroscience and Mental Health acknowledges the strong support from the Victorian Government and in particular the funding from the Operational Infrastructure Support Grant. The authors acknowledge the facilities and scientific and technical assistance of the National Imaging Facility, a National Collaborative Research Infrastructure Strategy (NCRIS) capability, at the Florey Institute of Neuroscience and Mental Health. The authors would also like to thank Professor Alan Connelly for his contributions to data collection, along with his valuable feedback and fruitful conversations, which contributed greatly to this manuscript.