Journal article
Can We Use Lung Function Thresholds and Respiratory Symptoms to Identify Pre-Chronic Obstructive Pulmonary Disease? A Prospective, Population-based Cohort Study
DJ Tan, CJ Lodge, E Haydn Walters, DS Bui, J Pham, AJ Lowe, G Bowatte, D Vicendese, B Erbas, DP Johns, AL James, P Frith, GS Hamilton, PS Thomas, R Wood-Baker, MLK Han, GR Washko, MJ Abramson, JL Perret, SC Dharmage
American Journal of Respiratory and Critical Care Medicine | AMER THORACIC SOC | Published : 2024
Abstract
Rationale: The term “pre–chronic obstructive pulmonary disease” (“pre-COPD”) refers to individuals at high risk of developing COPD who do not meet conventional spirometric criteria for airflow obstruction. New approaches to identifying these individuals are needed, particularly in younger populations. Objectives: To determine whether lung function thresholds and respiratory symptoms can be used to identify individuals at risk of developing COPD. Methods: The Tasmanian Longitudinal Health Study comprises a population-based cohort first studied in 1968 (at age 7 yr). Respiratory symptoms, pre- and post-bronchodilator (BD) spirometry, diffusing capacity, and static lung volumes were measured in..
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Funding Acknowledgements
Supported by funds from the National Health and Medical Research Council of Australia; the University of Melbourne, Clifford Craig Foundation; the Asthma Foundation of Victoria, the Asthma Foundation of Queensland, and the Asthma Foundation of Tasmania; the Royal Hobart Hospital Research Foundation; the Helen MacPherson Smith Trust; and GlaxoSmithKline. D.J.T. was supported by a National Health and Medical Research Council Postgraduate Scholarship and Royal Australian College of Physicians Woolcock Scholarship. The funding bodies had no direct role in the conduct of the study, statistical analysis or interpretation of the data, and preparation or approval of the manuscript.