Journal article
Updating estimates of Plasmodium knowlesi malaria risk in response to changing land use patterns across Southeast Asia
Ruarai J Tobin, Lucinda E Harrison, Meg K Tully, Inke ND Lubis, Rintis Noviyanti, Nicholas M Anstey, Giri S Rajahram, Matthew J Grigg, Jennifer A Flegg, David J Price, Freya M Shearer
PLoS Neglected Tropical Diseases | Public Library of Science (PLoS) | Published : 2024
Abstract
BACKGROUND: Plasmodium knowlesi is a zoonotic parasite that causes malaria in humans. The pathogen has a natural host reservoir in certain macaque species and is transmitted to humans via mosquitoes of the Anopheles Leucosphyrus Group. The risk of human P. knowlesi infection varies across Southeast Asia and is dependent upon environmental factors. Understanding this geographic variation in risk is important both for enabling appropriate diagnosis and treatment of the disease and for improving the planning and evaluation of malaria elimination. However, the data available on P. knowlesi occurrence are biased towards regions with greater surveillance and sampling effort. Predicting the spatial..
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Funding Acknowledgements
This research was supported by The University of Melbourne's Research Computing Services and the Petascale Campus Initiative (www.unimelb.edu.au). We thank Dr Timothy William for their support. We would like to also thank the Director General of Health Malaysia for the permission to publish this article.