Altered grey matter structural covariance in chronic moderate–severe traumatic brain injury

Abstract

Traumatic brain injury (TBI) alters brain network connectivity. Structural covariance networks (SCNs) reflect morphological covariation between brain regions. SCNs may elucidate how altered brain network topology in TBI influences long-term outcomes. Here, we assessed whether SCN organisation is altered in individuals with chronic moderate–severe TBI (≥ 10 years post-injury) and associations with cognitive performance. This case–control study included fifty individuals with chronic moderate–severe TBI compared to 75 healthy controls recruited from an ongoing longitudinal head injury outcome study. SCNs were constructed using grey matter volume measurements from T1-weighted MRI images. Global..