Journal article
Foxp1 Is Required for Renal Intercalated Cell Differentiation and Acid-Base Regulation
ST Wu, Y Feng, R Song, Y Qi, L Li, D Lu, Y Wang, W Wu, A Morgan, X Wang, Y Xia, R Liu, SI Alexander, J Wong, Y Zhang, X Zheng
Journal of the American Society of Nephrology | AMER SOC NEPHROLOGY | Published : 2024
Abstract
Key PointsFoxp1 is a key transcriptional factor for the differentiation of intercalated cells in collecting ducts.Dmrt2 and Hmx2 act downstream of Foxp1 to control the differentiation of type A and type B intercalated cells, respectively.Foxp1 and Dmrt2 are essential for body acid-base balance regulation.BackgroundKidney collecting ducts comprise principal cells and intercalated cells, with intercalated cells playing a crucial role in kidney acid-base regulation through H+and HCO3-secretion. Despite its significance, the molecular mechanisms controlling intercalated cell development remain incompletely understood.MethodsTo investigate the specific role of Foxp1 in kidney tubular system, we s..
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Awarded by National Key Research and Development Program of China
Funding Acknowledgements
The authors thank Equipment Sharing Platform at Tianjin Medical University for the support of imaging equipments. The authors thank Rui Wang for technical support in ChIP-seq analysis. The authors thank Zhongshuang Lv and the Center for Biological Imaging at Institute of Biophysics, Chinese Academy of Science for the technical support of electron microscopy.