A novel MYB::PAIP1 oncogenic fusion in pediatric blastic plasmacytoid dendritic cell neoplasm (BPDCN) is dependent on BCL2 expression and is sensitive to venetoclax

HJ Kosasih; G Healey; MS Brennan; S Bjelosevic; T Sadras; FB Jalud; T Ibnat; AP Ng; C Mayoh; J Mao; G Tax; LEA Ludlow; RW Johnstone; MJ Herold; SL Khaw; CE de Bock; PG Ekert

Journal article

A novel MYB::PAIP1 oncogenic fusion in pediatric blastic plasmacytoid dendritic cell neoplasm (BPDCN) is dependent on BCL2 expression and is sensitive to venetoclax

HJ Kosasih, G Healey, MS Brennan, S Bjelosevic, T Sadras, FB Jalud, T Ibnat, AP Ng, C Mayoh, J Mao, G Tax, LEA Ludlow, RW Johnstone, MJ Herold, SL Khaw, CE de Bock, PG Ekert

Hemasphere | WILEY | Published : 2024

DOI: 10.1002/hem3.1

Download PDF

University of Melbourne Researchers

Teresa Sadras Author

Ashley Ng Author

Louise Ludlow Author

Ricky Johnstone Author

Related Projects (1)

Unlocking hidden cancer drivers using transcriptome data

New sequencing technologies allow us to get an unbiased look at the molecular signalling in a tumour. However this information is very compl..

Grants

Awarded by Gilead Research Scholars

Funding Acknowledgements

The authors thank the Children's Cancer Centre Tissue Bank of Murdoch Children's Research Institute for the patient samples, the Translational Genomics Unit of Victorian Clinical Genetics Services, the Murdoch Children's Research Institute flow cytometry and imaging service, the Peter Mac Animal Core, and Walter and Eliza Hall Institute bioservices facilities for technical assistance. Tumor samples and coded data were supplied by the Children's Cancer Centre Biobank at the Murdoch Children's Research Institute and The Royal Children's Hospital (). The establishment and running of the Children's Cancer Centre Biobank is made possible through generous support by Cancer In Kids @ RCH (), the Royal Children's Hospital Foundation, and the Murdoch Children's Research Institute. We acknowledge Dhanya Menon, Rejhan Idrizi, and the Centre for Advanced Histology & Microscopy at the Peter MacCallum Cancer Centre for their assistance with histology.