Journal article
Stable potassium isotope distribution in mouse organs and red blood cells: Implication for biomarker development
MM Cui, F Moynier, BX Su, W Dai, Y Hu, D Rigoussen, B Mahan, M Le Borgne
Metallomics | OXFORD UNIV PRESS | Published : 2023
Abstract
Potassium (K) is an essential electrolyte for cellular functions in living organisms, and disturbances in K+ homeostasis could lead to various chronic diseases (e.g. hypertension, cardiac disease, diabetes, and bone health). However, little is known about the natural distribution of stable K isotopes in mammals and their application to investigate bodily homeostasis and/or as biomarkers for diseases. Here, we measured K isotopic compositions (δ41K, per mil deviation of 41K/39K from the NIST SRM 3141a standard) of brain, liver, kidney, and red blood cells (RBCs) from 10 mice (five females and five males) with three different genetic backgrounds. Our results reveal that different organs and RB..
View full abstractGrants
Awarded by Centre National de la Recherche Scientifique
Funding Acknowledgements
We deeply thank the two anonymous reviewers for insightful comments that have greatly improved our paper. We thank the DIMACAV+ (Domaine d'Interet Majeur, Astrophysique et Condition d'Apparition de la Vie) of the region Ile de France for providing part of the funding for the Nu Sapphire. We thank the financial support from the Mission for Transversal and Interdisciplinary Initiatives (MITI) from CNRS through the defi ISOTOP. We thank the support from IPGP multidisciplinary program PARI in this work. F.M. acknowledges financial support from the Horizon ERC DAI (# 101059236). M.M.C. deeply thanks the support of a scholarship from the University of Chinese Academy of Sciences.