Journal article
Mathematical models of Plasmodium vivax transmission: A scoping review
MN Anwar, L Smith, A Devine, S Mehra, CR Walker, E Ivory, E Conway, I Mueller, JM McCaw, JA Flegg, RI Hickson
Plos Computational Biology | PUBLIC LIBRARY SCIENCE | Published : 2024
Abstract
Plasmodium vivax is one of the most geographically widespread malaria parasites in the world, primarily found across South-East Asia, Latin America, and parts of Africa. One of the significant characteristics of the P. vivax parasite is its ability to remain dormant in the human liver as hypnozoites and subsequently reactivate after the initial infection (i.e. relapse infections). Mathematical modelling approaches have been widely applied to understand P. vivax dynamics and predict the impact of intervention outcomes. Models that capture P. vivax dynamics differ from those that capture P. falciparum dynamics, as they must account for relapses caused by the activation of hypnozoites. In this ..
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Awarded by National Health and Medical Research Council (NHMRC)
Awarded by NHMRC
Awarded by Australian Research Council
Awarded by NHMRC Australian Centre of Research Excellence in Malaria Elimination (ACREME)
Funding Acknowledgements
This work was supported by the National Health and Medical Research Council (NHMRC, GNT2016726 to LS, EC and IM) and the Department of Foreign Affairs and Trade Australia through the project Strengthening Preparedness in the Asia-Pacific Region through Knowledge (SPARK to LS, EC and IM). Research was supported through the NHMRC (2019152 to AD). The research was supported by the Australian Research Council (DP210101920 to JMM) and the NHMRC Australian Centre of Research Excellence in Malaria Elimination (ACREME, APP1134989 to JMM). The research was supported by the Australian Research Council (DP200100747, FT210100034 to JAF) and the NHMRC (APP2019093 to JAF). The contents of the published material are solely the responsibility of the individual authors and do not reflect the views of NHMRC. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.