Journal article
PD-1 regulates ILC3-driven intestinal immunity and homeostasis
N Jacquelot, L Xiong, WHJ Cao, Q Huang, H Yu, A Sayad, CJA Anttila, TM Baldwin, PF Hickey, D Amann-Zalcenstein, PS Ohashi, SL Nutt, GT Belz, C Seillet
Mucosal Immunology | ELSEVIER SCIENCE INC | Published : 2024
Open access
Abstract
Interleukin-(IL) 22 production by intestinal group 3 innate lymphoid cells (ILC3) is critical to maintain gut homeostasis. However, IL-22 needs to be tightly controlled; reduced IL-22 expression is associated with intestinal epithelial barrier defect while its overexpression promotes tumor development. Here, using a single-cell ribonucleic acid sequencing approach, we identified a core set of genes associated with increased IL-22 production by ILC3. Among these genes, programmed cell death 1 (PD-1), extensively studied in the context of cancer and chronic infection, was constitutively expressed on a subset of ILC3. These cells, found in the crypt of the small intestine and colon, displayed s..
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Funding Acknowledgements
This work was supported by grants and fellowships from the National Health and Medical Research Council (NHMRC) of Australia (1165443, 1122277, 1054925, 1135898 and 2008542 to G.T. B., 1165443, 1123000 and 2008090 to C.S.) , a grant to The University of Queensland Chair of Immunology (Frazer Institute, G.T.B.) , MS Australia (19-0614) , Cancer Council NSW (RG 21-05 to G.T.B. and N.J.) , Cure Cancer Australia and Cancer Australia through the Cancer Australia Priority-driven Cancer Research Scheme (1163990 N.J.) , Alberta Cancer Foundation/Arnie Charbonneau Cancer Institute laboratory start up package (N.J.) , Canadian Cancer Society Emerging Scholar Research Grant (grant #708072, to NJ) , the Dr. Robert C. Westbury Fund for Melanoma Research (N.J.) , scholarships of the Australian Government Research Training Program (Q.H.) , Melbourne Research Scholarship (W.C) and University of Queensland International Student Scholarship (H.Y) a CIHR Foundation Grant (P.S.O.) . The Translational Research Institute is supported by a grant from the Australian Government; WEHI is supported through Victorian State Government Operational Infrastructure Support and Australian Government NHMRC Independent Research Institutes Infrastructure Support Scheme (IRIISS) .r Canadian Cancer Society Emerging Scholar Research Grant (grant #708072, to NJ) , the Dr. Robert C. Westbury Fund for Mel-anoma Research (N.J.) , scholarships of the Australian Govern-ment Research Training Program (Q.H.) , Melbourne Research Scholarship (W.C) and University of Queensland International Student Scholarship (H.Y) a CIHR Foundation Grant (P.S.O.) . The Translational Research Institute is supported by a grant from the Australian Government; WEHI is supported through Victorian State Government Operational Infrastructure Support and Aus-tralian Government NHMRC Independent Research Institutes Infrastructure Support Scheme (IRIISS) .