Structural brain networks correlating with poststroke cognition

SLE Brownsett; LM Carey; D Copland; A Walsh; AJ Sihvonen

Journal article

Structural brain networks correlating with poststroke cognition

SLE Brownsett, LM Carey, D Copland, A Walsh, AJ Sihvonen

Human Brain Mapping | WILEY | Published : 2024

DOI: 10.1002/hbm.26665

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Abstract

Cognitive deficits are a common and debilitating consequence of stroke, yet our understanding of the structural neurobiological biomarkers predicting recovery of cognition after stroke remains limited. In this longitudinal observational study, we set out to investigate the effect of both focal lesions and structural connectivity on poststroke cognition. Sixty-two patients with stroke underwent advanced brain imaging and cognitive assessment, utilizing the Montreal Cognitive Assessment (MoCA) and the Mini-Mental State Examination (MMSE), at 3-month and 12-month poststroke. We first evaluated the relationship between lesions and cognition at 3 months using voxel-based lesion-symptom mapping. N..

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University of Melbourne Researchers

Leeanne Carey Author

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Grants

Awarded by Monash Medical Centre

Awarded by National Health and Medical Research Council (NHMRC)

Awarded by Commonwealth Science and Industrial Research Organisation (CSIRO) Flagship Collaborative Fund, NHMRC-Funded Centre of Research Excellence in Aphasia Recovery and Rehabilitation

Funding Acknowledgements

We express our gratitude to the study participants and staff of the participating hospitals across Victoria, Melbourne: Royal Melbourne Hospital, Austin Hospital, Epworth Hospital (Richmond), Monash Medical Centre and Western Hospital. Financial support for the work was provided by the National Health and Medical Research Council (NHMRC grants #1104194, #2004443 and #1113352), Commonwealth Science and Industrial Research Organisation (CSIRO) Flagship Collaborative Fund, NHMRC-Funded Centre of Research Excellence in Aphasia Recovery and Rehabilitation (#1153236) and Stroke Recovery and Rehabilitation (#1077898), Finnish Cultural Foundation (#191230), Maire Taponen Foundation, Orion Research Foundation sr and Signe and Ane Gyllenberg Foundation. Open access publishing facilitated by The University of Queensland, as part of the Wiley - The University of Queensland agreement via the Council of Australian University Librarians.