Journal article
Haemodynamics of stent-mounted neural interfaces in tapered and deformed blood vessels
Weijie Qi, Andrew Ooi, David B Grayden, Nicholas L Opie, Sam E John
Scientific Reports | Nature Portfolio | Published : 2024
Abstract
The endovascular neural interface provides an appealing minimally invasive alternative to invasive brain electrodes for recording and stimulation. However, stents placed in blood vessels have long been known to affect blood flow (haemodynamics) and lead to neointimal growth within the blood vessel. Both the stent elements (struts and electrodes) and blood vessel wall geometries can affect the mechanical environment on the blood vessel wall, which could lead to unfavourable vascular remodelling after stent placement. With increasing applications of stents and stent-like neural interfaces in venous blood vessels in the brain, it is necessary to understand how stents affect blood flow and tissu..
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Grants
Awarded by China Scholarship Council
Awarded by USA Department of Defense Office of the Congressionally Directed Medical Research Programs (CDMRP)
Awarded by University of Melbourne Research Computing Services
Funding Acknowledgements
The research was supported by research grants from the USA Department of Defense Office of the Congressionally Directed Medical Research Programs (CDMRP), EP170058 and National Health and Medical Research Council of Australia (NHMRC) Grant 1158912. The CFD modelling was supported by The University of Melbourne Research Computing Services and the Petascale Campus Initiative. Mr Weijie Qi is funded by the China Scholarship Council (CSC) from the Ministry of Education of P.R. China, CSC NO. 202008240002. The authors would like to thank Huakun Xin for his assistance with the design of the stent used in the study.