Journal article
Prognostic and functional importance of both overt and subclinical left ventricular systolic dysfunction in systemic sclerosis
Jessica L Fairley, Dylan Hansen, Susanna Proudman, Joanne Sahhar, Gene-Siew Ngian, Jenny Walker, Lauren V Host, Andre La Gerche, David Prior, Andrew Burns, Kathleen Morrisroe, Wendy Stevens, Mandana Nikpour, Laura Ross
Seminars in Arthritis and Rheumatism | Elsevier | Published : 2024
Abstract
Objectives: To quantify the frequency and clinical implications of systemic sclerosis (SSc)-associated left ventricular function (LV) impairment. Methods: Australian Scleroderma Cohort Study participants meeting ACR/EULAR criteria for SSc with ≥1 echocardiographic LVEF measurement were included. Overt LV dysfunction was indicated by reduced LV ejection fraction (LVEF) and subclinical LV dysfunction was measured using impaired LV global longitudinal strain (LV-GLS>-16 %). Those with secondary causes of LV dysfunction (myocardial ischaemia, valvulopathy and pulmonary arterial hypertension) were excluded. Chi-squared tests, two-sample t-tests or Wilcoxon rank-sum tests were used for between-gro..
View full abstractGrants
Awarded by Australian Rheumatology Association
Awarded by NHMRC Investigator Grant
Funding Acknowledgements
The Australian Scleroderma Cohort Study (ASCS) is supported by Janssen, Boehringer Inelheim, Scleroderma Australia, Scleroderma Victoria, Arthritis Australia, Musculoskeletal Australia (muscle, bone and joint health) , Australian Rheumatology Association and St. Vin-cent's Hospital Melbourne IT Department and Research Endowment Fund (REF) . JLF holds a NHMRC Postgraduate Scholarship GNT2013842, an Australian Government Research Training Program Scholarship and the University of Melbourne John Hayden Research Fellowship. KM holds NHMRC Investigator Grant GTN1197169. MN holds an NHMRC Investigator Grant (GNT1176538) . LR is the recipient of a RACP Australian Rheumatology Association & D.E.V. Starr Research Establishment Fellowship & Melbourne Medical School Strategic Grant for Outstanding Women. Data Availability Statement The authors confirm that the data supporting the findings of this study are available within the article and its supplementary materials.