Targeting thalamocortical circuits for closed-loop stimulation in Lennox-Gastaut syndrome

AEL Warren; CR Butson; MP Hook; LJ Dalic; JS Archer; E MacDonald-Laurs; FLWVJ Schaper; LA Hart; H Singh; L Johnson; KL Bullinger; RE Gross; MJ Morrell; JD Rolston

Journal article

Targeting thalamocortical circuits for closed-loop stimulation in Lennox-Gastaut syndrome

AEL Warren, CR Butson, MP Hook, LJ Dalic, JS Archer, E MacDonald-Laurs, FLWVJ Schaper, LA Hart, H Singh, L Johnson, KL Bullinger, RE Gross, MJ Morrell, JD Rolston

Brain Communications | Published : 2024

DOI: 10.1093/braincomms/fcae161

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Abstract

This paper outlines the therapeutic rationale and neurosurgical targeting technique for bilateral, closed-loop, thalamocortical stimulation in Lennox-Gastaut syndrome, a severe form of childhood-onset epilepsy. Thalamic stimulation can be an effective treatment for Lennox-Gastaut syndrome, but complete seizure control is rarely achieved. Outcomes may be improved by stimulating areas beyond the thalamus, including cortex, but the optimal targets are unknown. We aimed to identify a cortical target by synthesizing prior neuroimaging studies, and to use this knowledge to advance a dual thalamic (centromedian) and cortical (frontal) approach for closed-loop stimulation. Multi-modal brain network ..

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University of Melbourne Researchers

Aaron Warren Author

Linda Dalic Author

John Archer Author

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Grants

Awarded by LGS Foundation

Funding Acknowledgements

Group-level imaging data acquisition and prior analysis were supported by National Health and Medical Research Council project grants #628725 and #1108881. A.E.L.W. was supported by a research grant from the Lennox-Gastaut Syndrome Foundation (LGS Foundation). F.L.W.V.J.S. was supported by a National Institutes of Health and National Institute of Neurological Disorders and Stroke grant (R01NS127892). E.M.-L. was supported by the Clifford Family PhD scholarship and a Research Training Program scholarship from the Australian Government. J.D.R. was supported by a career development award (K23NS114178) from the National Institutes of Health and National Institute of Neurological Disorders and Stroke. A.E.L.W., C.R.B., M.P.H., L.J., M.J.M. and J.D.R. were supported by a National Institutes of Health and National Institute of Neurological Disorders and Stroke grant (UH3NS109557A1).