Journal article
Familial aggregation of seizure outcomes in four familial epilepsy cohorts
CA Ellis, D Tu, KL Oliver, HC Mefford, WA Hauser, J Buchhalter, MP Epstein, Q Cao, SF Berkovic, R Ottman
Epilepsia | WILEY | Published : 2024
DOI: 10.1111/epi.18004
Abstract
Objective: To assess the possible effects of genetics on seizure outcome by estimating the familial aggregation of three outcome measures: seizure remission, history of ≥4 tonic–clonic seizures, and seizure control for individuals taking antiseizure medication. Methods: We analyzed families containing multiple persons with epilepsy in four previously collected retrospective cohorts. Seizure remission was defined as being 5 and 10 years seizure-free at last observation. Total number of tonic–clonic seizures was dichotomized at <4 and ≥4 seizures. Seizure control in patients taking antiseizure medication was defined as no seizures for 1, 2, and 3 years. We used Bayesian generalized linear mixe..
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Awarded by National Institute of Neurological Disorders and Stroke
Funding Acknowledgements
C.A.E. was supported by the National Institute of Neurological Disorders and Stroke (NINDS) of the National Institutes of Health (NIH; Award Number K23NS121520), and by The American Academy of Neurology Susan S Spencer Clinical Research Training Scholarship. S.F.B. was supported by a National Health and Medical Research Council (NHMRC) Investigator Grant (APP1196637). The original studies that contributed data to this study were supported by the following NINDS NIH grants: U01NS077367 (Epi4K), U01NS053998 (Epilepsy Phenome/Genome Project), R01NS20656 (Epilepsy Family Study of Columbia University), and R01NS43472 (Genetic Epidemiology of Seizure Disorders in Rochester).