Investigation of immunology and neuropathology of influenza virus and arbovirus co-infection

Abstract

Viral co-infections can substantially impact antiviral responses, reduce protection and enhance immunopathology. Limited data exist on whether co-infection with influenza and other non-respiratory viruses affect disease outcomes and/or immune responses towards sequential or concurrent co-infections. As influenza viruses are prevalent worldwide, their geographical distribution overlap with neurotropic arboviruses. Hence, it is of key importance to investigate influenza and encephalitic arbovirus co-infections. The aim of this PhD thesis is to investigate the immune responses and immunopathology during co-infection with a respiratory influenza virus and neurotropic Alphavirus. We established..