Brain-age prediction: Systematic evaluation of site effects, and sample age range and size

Y Yu; HQ Cui; SS Haas; F New; N Sanford; K Yu; D Zhan; G Yang; JH Gao; D Wei; J Qiu; N Banaj; DI Boomsma; A Breier; H Brodaty; RL Buckner; JK Buitelaar; DM Cannon; X Caseras; VP Clark; PJ Conrod; F Crivello; EA Crone; U Dannlowski; CG Davey; L de Haan; GI de Zubicaray; A Di Giorgio; L Fisch; SE Fisher; B Franke; DC Glahn; D Grotegerd; O Gruber; RE Gur; RC Gur; T Hahn; BJ Harrison; S Hatton; IB Hickie; HE Hulshoff Pol; AJ Jamieson; TL Jernigan; J Jiang; AJ Kalnin; S Kang; NA Kochan; A Kraus; J Lagopoulos; L Lazaro; BC McDonald; C McDonald; KL McMahon; B Mwangi; F Piras; R Rodriguez-Cruces; J Royer; PS Sachdev; TD Satterthwaite; AJ Saykin; G Schumann; P Sevaggi; JW Smoller; JC Soares; G Spalletta; CK Tamnes; JN Trollor; D Van't Ent; D Vecchio; H Walter; Y Wang; B Weber; W Wen; LM Wierenga; SCR Williams; MJ Wu; GB Zunta-Soares; B Bernhardt; P Thompson; S Frangou; R Ge

Journal article

Brain-age prediction: Systematic evaluation of site effects, and sample age range and size

Y Yu, HQ Cui, SS Haas, F New, N Sanford, K Yu, D Zhan, G Yang, JH Gao, D Wei, J Qiu, N Banaj, DI Boomsma, A Breier, H Brodaty, RL Buckner, JK Buitelaar, DM Cannon, X Caseras, VP Clark Show all

Human Brain Mapping | WILEY | Published : 2024

DOI: 10.1002/hbm.26768

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Abstract

Structural neuroimaging data have been used to compute an estimate of the biological age of the brain (brain-age) which has been associated with other biologically and behaviorally meaningful measures of brain development and aging. The ongoing research interest in brain-age has highlighted the need for robust and publicly available brain-age models pre-trained on data from large samples of healthy individuals. To address this need we have previously released a developmental brain-age model. Here we expand this work to develop, empirically validate, and disseminate a pre-trained brain-age model to cover most of the human lifespan. To achieve this, we selected the best-performing model after ..

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University of Melbourne Researchers

Chris Davey Author

Ben Harrison Author

Alec Jamieson Author

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Funding Acknowledgements

[ "Avid Radiopharmaceuticals, Grant/AwardNumber: RF-2019-12370182; Bayer Oncology(Scientific Advisory Board); Eisai (ScientificAdvisory Board); Novo Nordisk (ScientificAdvisory Board); Big Data to Knowledge(BD2K) Program, Grant/Award Number: U54EB020403; The ENIGMA World Aging Center,Grant/Award Number: R56 AG058854; TheENIGMA Sex Differences Initiative,Grant/Award Number: R01 MH116147;Marato TV3 Foundation, Grant/AwardNumber: 01/2010; Carlos III Health Institute,Grant/Award Number: PI040829; Knut andAlice Wallenberg (KAW) Foundation; DondersCentre for Cognitive Neuroimaging; HumanGenetics and Cognitive Neurosciencedepartments of the Radboud universitymedical centre; Max Planck Institute forPsycholinguistics; Biobanking andBiomolecular Resources ResearchInfrastructure (Netherlands) (BBMRI-NL);Hersenstichting Nederland; NetherlandsOrganization for Scientific Research (NWO),i.e., the NWO Brain & Cognition ExcellenceProgram, Grant/Award Number: 433-09-229;Vici Innovation Program, Grant/AwardNumbers: 016-130-669, 91619115; EuropeanCommunity's Seventh Framework Programme(FP7/2007-2013), Grant/Award Numbers:602805, 603016, 602450, 278948; NIH, Grant/Award Numbers: R01MH62873, P30AG010133, R01 AG019771, R01 CA129769,P30 AG072976, R01 AG057739, U01AG024904, R01 LM013463, R01 AG068193,T32 AG071444, U01 AG068057, U01AG072177, RC2DA029475; NWO Large Investment grant, Grant/Award Number:1750102007010; ZonMW grant, Grant/Award Number: 60-60600-97-193; NWO,Grant/Award Numbers: 056-13-015,433-09-242; Radboud University Nijmegen Medical Center; University Medical Center Groningen and Accare; Vrije Universiteit Amsterdam; EU-AIMs programme; AIMS-2-TRIALS programme; Innovative Medicines Initiative Joint Undertaking grant, Grant/Award Numbers: 115300, 777394;European Federation of Pharmaceutical Industries and Associations (EFPIA); AUTISMSPEAKS; Autistica; SFARI; Horizon2020supported programme CANDY grant, Grant/Award Number: 847818; European Community's Horizon 2020 Programme (H2020/2014-2020), Grant/Award Numbers:643051, 667302, 847879; Netherlands Organization for Scientific Research (NWO) for the GUTS project, Grant/Award Number:024.005.011; National Institute for Health Research (NIHR) Maudsley Biomedical Research Centre at South London and Maudsley NHS Foundation Trust; King'sCollege London; German Research Foundation,Grant/Award Numbers: WA 1539/11-1, SFB-TRR58; National Institute of Mental Health(NIMH), Grant/Award Number:T32MH122394; Siemens Medical Solutions;American Epilepsy Society; EpilepsyFoundation; Epilepsy Therapy Project; FightAgainst Childhood Epilepsy and Seizures (F.A.C.E.S.); Parents Against Childhood Epilepsy(P.A.C.E.", "); GE/NFL Head Health Challenge I;Indiana State Department of Health SpinalCord and Brain Injury Fund Research GrantProgram; Project Development Team withinthe ICTSI NIH/NCRR, Grant/Award Number:RR025761; Italian ministry of health ricercacorrente 23; European Research Council,Grant/Award Number: ERC CoG PROSOCIAL681632; Research Council of Norway,Grant/Award Numbers: 223273, 288083,323951; South-Eastern Norway RegionalHealth Authority, Grant/Award Numbers:2019069, 2021070, 2023012, 500189;National Health & Medical Research Council(NHMRC) Program, Grant/Award Numbers:ID350833, ID568969, APP1093083;Australian Research Council (ARC) StrategicAward Grant of the Ageing Well, AgeingProductively Program, Grant/Award Number:401162; NHMRC Project (seed), Grant/AwardNumbers: 1024224, 1025243; NHMRCProject, Grant/Award Numbers: 1045325,1085606, 1064643, 1024570; NHMRCProgram grants, Grant/Award Numbers:568969, 1093083, R01AG059874,R01MH117601, R01NS107513,R01AG058854, P41EB015922; NHMRCInvestigator Grant, Grant/Award Number:GNT2009771; Department of Energy,Grant/Award Number: DEFG02-99ER62764;Canadian Institutes of Health Research,Grant/Award Number: 126053; NationalInstitute on Drug Abuse and the EuniceKennedy Shriver National Institute of ChildHealth & Human Development; HealthResearch Board Ireland; NIMH, Grant/AwardNumber: 1R01MH085667-01A1; JohnS. Dunn Foundation (Houston, Texas); PatRutherford Chair in Psychiatry (UTHealthHouston); Dutch Research Council,Grant/Award Number: NWO 51.02.61; NWO-NIHC Programs of excellence, Grant/AwardNumber: 433-09-220" ]