Journal article
Efficacy and tolerability of monoamine oxidase inhibitors for the treatment of depressive episodes in mood disorders: A systematic review and network meta-analysis
A Giménez-Palomo, AK Chamdal, N Gottlieb, M Lotfaliany, T Jokinen, EM Bastawy, K Adlington, N Benachar, S Dodd, I Pacchiarotti, E Vieta, M Berk, PRA Stokes
Acta Psychiatrica Scandinavica | Published : 2024
DOI: 10.1111/acps.13728
Abstract
Background: Monoamine oxidase inhibitors (MAOIs) are considered third-line treatments for treatment resistant depression; however, they are underused in clinical practice. Aims: This study aimed to assess the efficacy, tolerability, and acceptability of MAOIs for the treatment of depression in comparison with other antidepressant treatments. Methods: A systematic review and network meta-analysis of randomised clinical trials was performed to compare the efficacy, tolerability and acceptability between MAOIs and other antidepressant treatments for the treatment of depressive episodes. Results: A total of 83 double-blinded, randomised controlled trials were included in the analysis, with 7765 ..
View full abstractGrants
Awarded by Medical Research Council
Funding Acknowledgements
Spanish Ministry of Health, Instituto de Salud Carlos III, Grant/Award Numbers: CM21/00094, MV22/00057, 2017131; NHMRC Senior Principal Research Fellowship and Leadership 3 Investigator, Grant/Award Number: 1156072; FIS 2018 and 2021, Grant/Award Numbers: PI18/01001, PI21/00169; Spanish Ministry of Science and Innovation, Grant/Award Numbers: PI18/00805, PI21/00787; ISCIII-Subdireccion General de Evaluacion; European Regional Development Fund; Instituto de Salud Carlos III; CIBER of Mental Health (CIBERSAM); Secretaria d'Universitats i Recerca del Departament d'Economia i Coneixement, Grant/Award Number: 2017 SGR 1365; CERCA Programme, and the Departament de Salut de la Generalitat de Catalunya, Grant/Award Number: SLT006/17/00357; EU.3.1.1. Understanding health, wellbeing and disease, Grant/Award Number: 754907; EU.3.1.3. Treating and managing disease, Grant/Award Number: 945151