Journal article
Trophoblast Side-Population Markers are Dysregulated in Preeclampsia and Fetal Growth Restriction
GP Wong, S Hartmann, DG Simmons, S Ellis, O Nonn, P Cannon, TV Nguyen, A Nguyen, LA Bartho, S Tong, NJ Hannan, TJ Kaitu’u-Lino
Stem Cell Reviews and Reports | SPRINGER | Published : 2024
Abstract
Dysregulated progenitor cell populations may contribute to poor placental development and placental insufficiency pathogenesis. Side-population cells possess progenitor properties. Recent human trophoblast side-population isolation identified enrichment of 8 specific genes (CXCL8, ELL2, GATA6, HK2, HLA-DPB1, INTS6, SERPINE3 and UPP1) (Gamage et al. 2020, Stem Cell Rev Rep). We characterised these trophoblast side-population markers in human placenta and in placental insufficiency disorders: preeclampsia and fetal growth restriction (FGR). Trophoblast side-population markers localised to mononuclear trophoblasts lining the placental villous basement membrane in preterm control, preeclamptic a..
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Grants
Awarded by Japan Agency for Medical Research and Development
Funding Acknowledgements
The authors would like to acknowledge research midwives Kaitlin Constable, Melissa Sutton, Gabrielle Pell, Genevieve Christophers, Rachel Murdoch, Alison Abboud, the clinical staff, and patients at the Mercy Hospital for Women (Heidelberg) for the provision of samples used in this work. We also thank the pathology, health information services, and antenatal clinic staff at the Mercy Hospital for Women in their assistance in conducting this research. First trimester trophoblast stem cells were obtained from the RIKEN BRC through the National BioResource Project of the MEXT/AMED, Japan.