High expression of oleoyl-ACP hydrolase underpins life-threatening respiratory viral diseases

Grants

Funding Acknowledgements

Research was funded by the National Health and Medical Research Council of Australia: NHMRC-L1 to K.K. (#1173871), NHMRC-EL1 to T.H.O.N. (#1194036), and NHMRC Ideas Grant to B.Y.C. (#2001346). For purposes of open access, the authors have applied a CC BY public copyright license to any Author Accepted Manuscript version arising from this submission. We thank Weisan Chen for nucleoprotein reagents; Michael Inouye for assistance with analysis; Marumi Ohno for expertise in LD inhibitors; Drs. Loudovaris, Mannering, and Godfrey for spleen/thymus samples; and Richard Berger, Jinchun Sun, Gustavo Palacios, Armondo Flores-Torres, Lindsay Brown, and Shawn Campagna for lipidomic data assistance. We acknowledge the UoM Cytometry Platform, the UoM Mass Spectrometry/Bio21 Proteomics Facility Molecular Science and Biotechnology Institute, Latrobe Bioimaging Facility, St. Jude Children's Research Hospital Hartwell Center, Australian Phenomics Network Histopathology, the Organ Pathology Service, and the UoM Slide Scanning Service. olah<SUP>-/-</SUP> mice generation was supported by Phenomics Australia/Australian Government through National Collaborative Research Infrastructure Strategy. Reagents were obtained through NIH Biodefense and Emerging Infections Research Resources Repository, NIAID/NIH: Polyclonal Anti-Influenza Virus H3-Hemagglutinin, A/Hong Kong/1/68 (antiserum/Goat), and NR-3118. X.J. received a China Council-UoM Scholarship. J.C.C. and P.G.T. were supported by NIH NIAID R01-AI136514, U01AI150747, and ALSAC at St. Jude. R.C.M. is supported by a Ruth Kirschstein National Research Service Award Individual Postdoctoral Fellowship (#F32AI157296). A.G.R. and P.G.T. are supported by NIH NIAID R01-AI154470, C.E.v.d.S. by ARC-DECRA (#DE220100185), and N.E.S. by an ARC-Future Fellowship (#FT200100270). This project was funded with federal funds from the National Institute of Allergy and Infectious Diseases, the National Institutes of Health, the Department of Health and Human Services, contract #75N93021C00018 (NIAID Centers of Excellence for Influenza Research and Response, CEIRR) to K.K., P.G.T., and A.G.R. and contract #75N93021C00016 to H.S.S. We thank Overcoming COVID-19 Investigators for pediatric COVID-19 samples, supported by the US Centers for Disease Control and Prevention (individuals and enrolling sites: Adrienne Randolph, Janet Chou, Tanya Novak, Suden Kucukak, and Takuma Kobayashi, Boston Children's Hospital, Massachusetts; Michele Kong, Children's of Alabama, Birmingham; Mary Gaspers and Katri Typpo, Banner Children's Hospital, Tucson, Arizona; Katherine Irby and Ronald Sanders, Jr., Arkansas Children's Hospital, Little Rock; Natalie Cvijanovich, UCSF Benioff Children's Hospital, Oakland, California; Matt Zinter, <EM><STRONG> </STRONG></EM>UCSF Benioff Children's Hospital, California; Aline Maddux, Children's Hospital Colorado, Aurora; Brandon Chatani, Holtz Children's Hospital, Miami, Florida; Keiko Tarquinio, Children's Healthcare of Atlanta at Egleston, Atlanta; Bria Coates, Ann & Robert Lurie Children's Hospital, Chicago, Illinois; Courtney M. Rowan, MSCR, Riley Children's Hospital, Indianapolis, Indiana; Heidi Flori and Mary Dahmer, University of Michigan CS Mott Children's Hospital, Ann Arbor; Janet Hume, University of Minnesota Masonic Children's Hospital, Minneapolis; Emily Levy, Mayo Clinic, Rochester, Minnesota; Charlotte V. Hobbs, University of Mississippi Medical Center, Jackson; Jennifer Schuster, Children's Mercy Hospital, Kansas City; Melissa Cullimore, Children's Hospital & Medical Center, Omaha, Nebraska; Shira Gertz, Cooperman Barnabas Medical Center, Livingston, New Jersey; Stephanie Schwartz and Tracie Walker, University of North Carolina, Chapel Hill, North Carolina; Ryan Nofziger, Akron Children's Hospital, Ohio; Mary Allen Staat, Cincinnati Children's Hospital, Ohio; Steven Shein, University Hospitals Rainbow Babies and Children's Hospital, Cleveland, Ohio; Julie Fitzgerald, Children's Hospital of Philadelphia, Pennsylvania; Elizabeth Mack, MUSC Shawn Jenkins Children's Hospital, Charleston, South Carolina; Natasha Halasa, Monroe Carell Jr. Children's Hospital, Vanderbilt, Nashville, Tennessee; Laura Loftis, Texas Children's Hospital, Houston, Texas; and Hillary Crandall, Primary Children's Hospital, Salt Lake City, Utah). We thank CIViC-19 Investigators for adult COVID-19 plasma samples and Nicholas Hysmith; Chloe Hundman; Kristin McNair, RN; and Laura Boywid, RN, for clinical data. Some images were created with BioRender.com.