Journal article
HIV transcription persists in the brain of virally suppressed people with HIV
Janna Jamal Eddine, Thomas A Angelovich, Jingling Zhou, Sarah J Byrnes, Carolin Tumpach, Nadia Saraya, Emily Chalmers, Rory A Shepherd, Abigail Tan, Stephanie Marinis, Paul R Gorry, Jacob D Estes, Bruce J Brew, Sharon R Lewin, Sushama Telwatte, Michael Roche, Melissa J Churchill
PLoS Pathogens | Public Library of Science (PLoS) | Published : 2024
Abstract
HIV persistence in the brain is a barrier to cure, and potentially contributes to HIV-associated neurocognitive disorders. Whether HIV transcription persists in the brain despite viral suppression with antiretroviral therapy (ART) and is subject to the same blocks to transcription seen in other tissues and blood, is unclear. Here, we quantified the level of HIV transcripts in frontal cortex tissue from virally suppressed or non-virally suppressed people with HIV (PWH). HIV transcriptional profiling of frontal cortex brain tissue (and PBMCs where available) from virally suppressed (n = 11) and non-virally suppressed PWH (n = 13) was performed using digital polymerase chain reaction assays (dP..
View full abstractRelated Projects (2)
Grants
Awarded by NIDA NIH HHS