Journal article
Sequential and parallel testing for microbiological confirmation of tuberculosis disease in children in five low-income and middle-income countries: a secondary analysis of the RaPaed-TB study.
Laura Olbrich, Zoe Franckling-Smith, Leyla Larsson, Issa Sabi, Nyanda Elias Ntinginya, Celso Khosa, Denise Banze, Marriott Nliwasa, Elizabeth Lucy Corbett, Robina Semphere, Valsan Philip Verghese, Joy Sarojini Michael, Marilyn Mary Ninan, Elmar Saathoff, Timothy Daniel McHugh, Alia Razid, Stephen Michael Graham, Rinn Song, Pamela Nabeta, Andre Trollip Show all
The Lancet Infectious Diseases | Elsevier | Published : 2024
Abstract
BACKGROUND: Despite causing high mortality worldwide, paediatric tuberculosis is often undiagnosed. We aimed to investigate optimal testing strategies for microbiological confirmation of tuberculosis in children younger than 15 years, including the yield in high-risk subgroups (eg, children younger than 5 years, with HIV, or with severe acute malnutrition [SAM]). METHODS: For this secondary analysis, we used data from RaPaed-TB, a multicentre diagnostic accuracy study evaluating novel diagnostic assays and testing approaches for tuberculosis in children recruited from five health-care centres in Malawi, Mozambique, South Africa, Tanzania, and India conducted between Jan 21, 2019, and June ..
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Awarded by Medical Research Council