Journal article
Pubertal hormones and mental health problems in children and adolescents: a systematic review of population-based studies
D Luo, SG Dashti, SM Sawyer, N Vijayakumar
Eclinicalmedicine | ELSEVIER | Published : 2024
Abstract
Given the increased prevalence of mental health problems during adolescence, there is considerable interest in understanding potential biological mechanisms including the contribution of pubertal hormones. This systematic review of 55 papers aimed to synthesize the evidence for the effect of pubertal hormones on the risk for mental health problems in children and adolescents. The pattern of findings from included studies suggested associations of testosterone and estradiol with certain types of mental health problems, but with inconsistencies relating to DHEA and DHEA-S. However, the state of evidence for the causal effects of hormones was determined to be weak given assessment of bias from ..
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Awarded by China Scholarship Council
Funding Acknowledgements
We would like to thank Poh Chua (Librarian, Royal Children's Hospital, Parkville, VIC, Australia) for her assistance in developing the search strategy in this review. DL is supported by a China Scholarship Council-University of Melbourne PhD Scholarship (grant number 202006010040). SMS (GNT1196999) and SGD (GNT2027171) are supported by National Health and Medical Research Council Investigator Grants. SMS, and DL are affiliated with the National Health and Medical Research Council funded Centre of Research Excellence for Driving Global Investment in Adolescent Health (GNT 1171981) . There was no other funding source for this review. All authors had full access to all data in the study and accept the responsibility to submit for publication.