Journal article
Six-month outcomes after traumatic brain injury in the Augmented versus Routine Approach to Giving Energy multicentre, double-blind, randomised controlled Trial (TARGET)
K Wittholz, K Fetterplace, LA Chapple, EJ Ridley, M Finnis, J Presneill, M Chapman, S Peake, R Bellomo, A Karahalios, AM Deane
Australian Critical Care | ELSEVIER SCIENCE INC | Published : 2025
Abstract
Background: Critically ill patients with a traumatic brain injury (TBI) may require prolonged intensive care unit (ICU) admission and hence receive greater exposure to hospital enteral nutrition. It is unknown if augmented energy delivery with enteral nutrition during ICU admission impacts quality of life in survivors or gastrointestinal tolerance during nutrition delivery in the ICU. Objectives: The objective of this study was to compare health-related quality of life, using the EuroQol five-dimensions five-level visual analogue scale at 6 months, in survivors who presented with a TBI and received augmented energy (1.5 kcal/ml) to those who received routine energy (1.0 kcal/ml). Secondary o..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
The TARGET trial was supported by grants from the National Health and Medical Research Council of Australia (Project grant no. 1078026) and the Health Research Council of New Zealand (Project grant no. 15/141). In-kind support was provided by Fresenius Kabi Deutschland GmbH for the supply and delivery of study enteral nutrition. TARGET ClinicalTrials.gov number NCT02306746.