Journal article
Bridging big data in the ENIGMA consortium to combine non-equivalent cognitive measures
Eamonn Kennedy, Shashank Vadlamani, Hannah M Lindsey, Pui-Wa Lei, Mary Jo-Pugh, Paul M Thompson, David F Tate, Frank G Hillary, Emily L Dennis, Elisabeth A Wilde, undefined ENIGMA Clinical Endpoints Working Group
Scientific Reports | Nature Portfolio | Published : 2024
Abstract
Investigators in neuroscience have turned to Big Data to address replication and reliability issues by increasing sample size. These efforts unveil new questions about how to integrate data across distinct sources and instruments. The goal of this study was to link scores across common auditory verbal learning tasks (AVLTs). This international secondary analysis aggregated multisite raw data for AVLTs across 53 studies totaling 10,505 individuals. Using the ComBat-GAM algorithm, we isolated and removed the component of memory scores associated with site effects while preserving instrumental effects. After adjustment, a continuous item response theory model used multiple memory items of varyi..
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Funding Acknowledgements
Spanish Ministry of Science and Innovation, Instituto de Salud Carlos III: PI15-00852, PI18-00945, JR19-00024, PI17-00481, PI20-00721, Sara Borrell contract (CD19-00149); European Union: NextGenerationEU (PMP21/00051), PI19/01024, Structural Funds, Seventh Framework Program, H2020 Program under the Innovative Medicines Initiative 2 Joint Undertaking: Project PRISM-2 (Grant agreement No.101034377), Project AIMS-2-TRIALS (Grant agreement No 777394), Horizon Europe; National Institutes of Health: U01MH124639, P50MH115846, R01MH113827, R25MH080663, K08MH068540, R01NS100973, R01EB006841, P20GM103472, RO1MH083553, T32MH019535, R01 HD061504, RO1MH083553, R01AG050595, R01AG076838, R01AG060470, R01AG064955, P01AG055367, K23MH095661, R01MH094524, R01MH121246, T32MH019535, R01NS124585, R01NS122827, R61NS120249, R01NS122184, U54EB020403, R01MH116147, R56AG058854, P41EB015922, R01MH111671, P41RR14075, M01RR01066, R01EB006841, R01EB005846, R01 EB000840, RC1MH089257, U24 RR021992, NCRR 5 month-RR001066 (MGH General Clinical Research Center); NSF: 2112455; Madrid Regional Government: B2017/BMD-3740 AGES-CM-2; Dalhousie Medical Research Foundation; Research Nova Scotia, RNS-NHIG-2021-1931; US Department of Defense: Award # AZ150145; US Department of Veterans Affairs: 1I01RX003444; NJ Commission on TBI Research Grants: CBIR11PJT020, CBIR13IRG026: Department of Psychology, University of Oslo; Sunnaas Rehabilitation Hospital: HF F32NS119285; Canadian Institutes of Health Research: Grant 166098; Neurological Foundation of New Zealand; Canterbury Medical Research Foundation, University of Otago. Biogen US, Investigator-initiated grant; Italian Ministry of Health: RF-2019-12370182, Ricerca Corrente RC 23; National Institute on Aging: National Health and Medical Research Council, Investigator Grant APP1176426; PA Health Research: Grant SAP #4100077082 to Dr. Hillary; La Caixa Foundation, ID: 100010434, fellowship code: LCF/BQ/PR22/11920017; Research Council of Norway: 248238; Health Research Council of New Zealand: Sir Charles Hercus Early Career Development (17/039), 14-440; South-Eastern Norway Regional Health Authority, 2018076; Norwegian ExtraFoundation for Health and Rehabilitation: 2015/ FO5146, 2015044; Stiftelsen K.G. Jebsen, SKGJ MED-02; German Research Foundation: DFG grant FOR2107 to Andreas Jansen, JA 1890/7-1, JA 1890/7-2, DFG grant FOR2107 to Igor Nenadi & cacute;, NE2254/1-2,NE2254/3-1,NE2254/4-1, DFG grant FOR2107, KI588/14-1 and FOR2107, KI588/14-2, DFG, grant FOR2107 DA1151/5-1 and DA1151/5-2, SFB-TRR58, Projects C09 and Z02; Central Norway Regional Health Authority (RHA) and the Norwegian University of Science and Technology (NTNU); National Health and Medical Research Council: APP1020526; Brain Foundation, Wicking Trust, Collie Trust, Sidney and Fiona Myer Family Foundation. U.S. Army Medical Research and Materiel Command (USAMRMC): Award #13129004; Department of Energy: DE- FG02-99ER62764: Mind Research Network, National Association for Research in Schizophrenia and Affective Disorders: Young Investigator Award, Blowitz Ridgeway and Essel Foundations, NOW ZonMw TOP 91211021, UCLA Easton Clinic for Brain Health, UCLA Brain Injury Research Center, Stan and Patty Silver, Clinical and Translational Research Center: UL1RR033176, UL1TR000124; Mount Sinai Institute for NeuroAIDS Disparities, VA Rehab SPIRE, CDMRP PRAP, VA RR&D IK2RX002922, Veski Fellowship, Femino Foundation grant, Fundacion Familia Alonso, Fundacion Alicia Koplowitz, CIBERSAM, Madrid Regional Government (B2017/BMD-3740 AGES-CM-2), 2019R1C1C1002457, 21-BR-03-01, 2020M3E5D9079910, 21-BR-03-01, Interdisciplinary Center for Clinical Research (IZKF) of the medical faculty of Munster.