Journal article
Autoantibodies to BACE1 promote Aβ accumulation and neurodegeneration in Alzheimer's disease
Ye-Ran Wang, Xiao-Qin Zeng, Jun Wang, Christopher J Fowler, Qiao-Xin Li, Xian-Le Bu, James Doecke, Paul Maruff, Ralph N Martins, Christopher C Rowe, Colin L Masters, Yan-Jiang Wang, Yu-Hui Liu
Acta Neuropathologica | Springer | Published : 2024
Abstract
The profile of autoantibodies is dysregulated in patients with Alzheimer's disease (AD). Autoantibodies to beta-site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1) are present in human blood. This study aims to investigate the clinical relevance and pathophysiological roles of autoantibodies to BACE1 in AD. Clinical investigations were conducted in two independent cohorts, the Chongqing cohort, and the Australian Imaging, Biomarkers, and Lifestyle (AIBL) cohort. The Chongqing cohort included 55 AD patients, 28 patients with non-AD dementia, and 70 cognitively normal subjects (CN). The AIBL cohort included 162 Aβ-PET- CN, 169 Aβ-PET+ cognitively normal subjects (preclinical AD), an..
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Awarded by National Natural Science Foundation of China
Awarded by Innovative Research Group Project of the National Natural Science Foundation of China
Awarded by National-Level Reserve Talent Program of the Chongqing Health Commission