Journal article
Improvements in body composition, cardiometabolic risk factors and insulin sensitivity with trenbolone in normogonadic rats
DG Donner, BR Beck, AC Bulmer, AK Lam, EF Du Toit
Steroids | ELSEVIER SCIENCE INC | Published : 2015
Abstract
Trenbolone (TREN) is used for anabolic growth-promotion in over 20 million cattle annually and continues to be misused for aesthetic purposes in humans. The current study investigated TREN's effects on body composition and cardiometabolic risk factors; and its tissue-selective effects on the cardiovascular system, liver and prostate. Male rats (n = 12) were implanted with osmotic infusion pumps delivering either cyclodextrin vehicle (CTRL) or 2 mg/kg/day TREN for 6 weeks. Dual-energy X-ray Absorptiometry assessment of body composition; organ wet weights and serum lipid profiles; and insulin sensitivity were assessed. Cardiac ultrasound examinations were performed before in vivo studies asses..
View full abstractGrants
Funding Acknowledgements
The present study was financially supported by the Heart Foundation Research Centre, the Griffith Health Institute and the School of Medical Science, Griffith University, Australia. These funds were used to support the animal purchase and housing costs; and the collection, analysis and interpretation of data compiled in the current study.