Journal article
Left ventricular volume as a predictor of exercise capacity and functional independence in individuals with normal ejection fraction
Stephanie Rowe, Wouter L'Hoyes, Mauricio Milani, Luke Spencer, Stephen Foulkes, Elizabeth Paratz, Kristel Janssens, Jan Stassen, Boris Delpire, Rik Pauwels, Sara Moura-Ferreira, Maarten Falter, Youri Bekhuis, Lieven Herbots, Mark J Haykowsky, Guido Claessen, Andre La Gerche, Jan Verwerft
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY | OXFORD UNIV PRESS | Published : 2024
Abstract
AIMS: Low cardiorespiratory fitness (CRF) is associated with functional disability, heart failure and mortality. Left ventricular (LV) end-diastolic volume (LVEDV) has been linked with CRF, but its utility as a diagnostic marker of low CRF has not been tested. METHODS: This multi-center international cohort examined the relationship between LV size on echocardiography and CRF (peak oxygen uptake [peak VO2] from cardiopulmonary exercise testing) in individuals with LV ejection fraction ≥50%. Absolute and BSA-indexed LVEDV (LVEDVi) were tested as predictors of low CRF and functional disability (peak VO2 <1100ml/min or <18 ml/kg/min) and compared against candidate measures of cardiac structure ..
View full abstractGrants
Awarded by Flanders Research Foundation FWO
Funding Acknowledgements
S.R. is supported by the NHMRC, the National Heart Foundation of Australia, and the Elizabeth and Vernon Puzey PhD Scholarships. E.P. is supported by a Mamoma Foundation Fellowship, National Heart Foundation of Australia Vanguard Grant, Sylvia & Charles Viertel Clinical Investigator Grant, University of Melbourne Wilma Beswick Fellowship, and Strategic Grant for Outstanding Women. A.L.G. is supported by an NHMRC Investigator Grant. M.J.H. is funded, in part, by an endowed research chair in ageing and quality of life in the Faculty of Nursing, University of Alberta. M.F. and Y.B. received funding through the Flanders Research Foundation FWO (file numbers 1SE1222N and T004420N, respectively).