Journal article
Immunological and molecular features of the tumor microenvironment of long-term survivors of ovarian cancer
BH Nelson, P Hamilton, MT Phung, K Milne, B Harris, S Thornton, D Stevens, S Kalaria, K Singh, CM Laumont, E Moss, A Alimujiang, NS Meagher, A Bolithon, S Fereday, CJ Kennedy, J Hendley, D Ariyaratne, K Alsop, N Traficante Show all
Journal of Clinical Investigation | Published : 2024
DOI: 10.1172/JCI179501
Abstract
BACKGROUND. Despite an overall poor prognosis, about 15% of patients with advanced-stage tubo-ovarian high-grade serous carcinoma (HGSC) survive 10 or more years after standard treatment. METHODS. We evaluated the tumor microenvironment of this exceptional, understudied group using a large international cohort enriched for long-term survivors (LTS; 10+ years; n = 374) compared with mid-term (MTS; 5–7.99 years; n = 433) and short-term survivors (STS; 2–4.99 years; n = 416). Primary tumor samples were immunostained and scored for intraepithelial and intrastromal densities of 10 immune-cell subsets (including T cells, B cells, plasma cells, myeloid cells, PD-1+ cells, and PD-L1+ cells) and epit..
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Grants
Awarded by Mayo Foundation for Medical Education and Research