Association between wildfire-related PM2.5 and epigenetic aging: A twin and family study in Australia

Abstract

Wildfire-related PM2.5 has been associated with various adverse health outcomes, but its association with epigenetic aging remains unclear. This study examined the association between wildfire-related PM2.5 exposure and epigenetic aging using DNA methylation data from a twin and family study. With a within-sibship analysis, we found that each 1 µg/m3 increase in annual wildfire-related PM2.5 was associated with a 0.25-year (95 % CI: 0.04, 0.47) increase in GrimAge1 acceleration and a 0.36-year (95 % CI: 0.12, 0.59) increase in GrimAge2 acceleration. Subgroup analyses found that participants aged ≥ 60 years, those with a history of current or former smoking and alcohol consumption, and those ..