Journal article
Rapid oxygen titration following cardiopulmonary resuscitation mitigates cerebral overperfusion and striatal mitochondrial dysfunction in asphyxiated newborn lambs
S Badurdeen, R Galinsky, CT Roberts, KJ Crossley, VA Zahra, A Thiel, Y Pham, PG Davis, SB Hooper, GR Polglase, EJ Camm
Journal of Cerebral Blood Flow and Metabolism | SAGE PUBLICATIONS INC | Published : 2025
Abstract
Asphyxiated neonates must have oxygenation rapidly restored to limit ongoing hypoxic-ischemic injury. However, the effects of transient hyperoxia after return of spontaneous circulation (ROSC) are poorly understood. We randomly allocated acutely asphyxiated, near-term lambs to cardiopulmonary resuscitation in 100% oxygen (“standard oxygen”, n = 8) or air (n = 7) until 5 minutes after ROSC, or to resuscitation in 100% oxygen immediately weaned to air upon ROSC (“rapid-wean”, n = 7). From 5 minutes post-ROSC, oxygen was titrated to target preductal oxygen saturation between 90–95%. Cerebral tissue oxygenation was transiently but markedly elevated following ROSC in the standard oxygen group com..
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Grants
Awarded by National Health and Medical Research Council
Funding Acknowledgements
The author(s) disclosed receipt of the following financial sup-port for the research, authorship, and/or publication of thisarticle: This study was supported by the National Health and Medical Research Council (NHMRC) through a Project grant (APP1158494) and Fellowships (CTR: APP1175634,PGD: APP1059111, SBH: APP545921, GRP: APP1105526).SB was supported by an Australian Government Research Training Program Scholarship. The funders had no role in the study design, in the collection, analysis and interpretation of data; in the writing of the manuscript; and in the decision to submit the manuscript for publication.