Journal article
Progression and clinical implications of frailty in patients with systemic sclerosis
Jessica FAIRLEY, Dylan Hansen, Susanna Proudman, Joanne Sahhar, Gene-Siew NGIAN, Jennifer Walker, Lauren Host, Wendy Stevens, Mandana Nikpour, Laura Ross
Clinical Rheumatology | Springer | Published : 2024
Abstract
Introduction/objectives: To identify the frequency, correlates and progression of frailty in systemic sclerosis (SSc). Method: All Australian Scleroderma Cohort Study participants meeting ACR/EULAR criteria with a calculable FRAIL Scale score were included. FRAIL Scale scores were calculated annually and were used to group participants as ‘robust’, ‘pre-frail’ or ‘frail’. Progression of frailty over time was examined by comparing first-recorded, highest-recorded and last-recorded FRAIL Scale scores for each participant. Determinants of frailty at each visit were evaluated with ordinal logistic regression. Survival was analysed using Cox hazard modelling. Results: Of 1703 participants, 14% ..
View full abstractGrants
Awarded by NHMRC Postgraduate Scholarship
Awarded by NHMRC
Funding Acknowledgements
The Australian Scleroderma Cohort Study (ASCS) is supported by Janssen, Boehringer Ingelheim, Scleroderma Australia, Scleroderma Victoria, Arthritis Australia, Musculoskeletal Australia (muscle, bone and joint health), Australian Rheumatology Association and St. Vincent's Hospital Melbourne IT Department and Research Endowment Fund (REF). JLF holds a NHMRC Postgraduate Scholarship (GNT2013842), an Australian Government Research Training Program Scholarship and the University of Melbourne John Hayden Research Fellowship. MN holds an NHMRC Investigator Grant (GNT1176538). LR is the recipient of a RACP Australian Rheumatology Association & D.E.V. Starr Research Establishment Fellowship & Melbourne Medical School Strategic Grant for Outstanding Women.