Journal article
Levofloxacin for the Prevention of Multidrug-Resistant Tuberculosis in Vietnam
Greg J Fox, Nguyen Viet Nhung, Nguyen Cam Binh, Nguyen Binh Hoa, Frances L Garden, Andrea Benedetti, Pham Ngoc Yen, Nguyen Kim Cuong, Emily L MacLean, H Manisha Yapa, David W Dowdy, Nguyen Huu Lan, Elyse Guevara-Rattray, Pham Duc Cuong, Ori Solomon, Marcel A Behr, Ben J Marais, Steven M Graham, Dick Menzies, Nguyen Thu Anh Show all
New England Journal of Medicine | Massachusetts Medical Society | Published : 2024
Abstract
BACKGROUND: Prevention of drug-resistant tuberculosis is a global health priority. However, trials evaluating the effectiveness of treating Mycobacterium tuberculosis infection among contacts of persons with drug-resistant tuberculosis are lacking. METHODS: We conducted a double-blind, randomized, controlled trial comparing 6 months of daily levofloxacin (weight-based doses) with placebo to treat M. tuberculosis infection. The trial population comprised household contacts of persons with bacteriologically confirmed rifampicin-resistant or multidrug-resistant (MDR) tuberculosis in Vietnam. Contacts of any age with a positive tuberculin skin test or immunologic impairment were eligible. The ..
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Awarded by National Health and Medical Research Council