Journal article
Effect of bicalutamide on serum total testosterone concentration in transgender adults: a case series
LM Angus, QV Hong, AS Cheung, BJ Nolan
Therapeutic Advances in Endocrinology and Metabolism | SAGE PUBLICATIONS LTD | Published : 2024
Open access
Abstract
Background: There is interest in repurposing bicalutamide for gender-affirming hormone therapy, but little data regarding efficacy and safety in the transgender population. Objectives: To determine the effect of bicalutamide on serum total testosterone concentrations and liver function. Given bicalutamide is a pure androgen receptor antagonist, we hypothesized that serum total testosterone concentrations would be higher than the cisgender female reference range and those recommended for transgender individuals in consensus guidelines. Design: Case series. Methods: We identified transgender people attending outpatient clinics who were using bicalutamide for gender affirmation. The primary out..
View full abstractGrants
Funding Acknowledgements
The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: Dr. Angus is supported by the Australian Commonwealth Government Research Training Program scholarship. A/Prof. Cheung is supported by an Australian Government National Health and Medical Research Council Investigator Grant (#2008956). Dr. Nolan is supported by a Royal Australasian College of Physicians-Endocrine Society of Australia Research Establishment Fellowship.