Journal article
A 1,000-Genome Map for Multiple Myeloma and Its Precursor Stages, and Its Impact on Clinical Outcome
Jean-Baptiste Alberge, Ankit K Dutta, Andrea Poletti, Tim HH Coorens, Elizabeth D Lightbody, Rosa Toenges, Xavi Loinaz, Sofia Wallin, Andrew Dunford, Oliver Priebe, Cody J Boehner, Erica M Horowitz, Nang Kham Su, Hadley Barr, Laura Hevenor, Katherine Towle, Rashmika Beesam, Jenna D Beckwith, Jacqueline Perry, David M Cordas dos Santos Show all
Blood | American Society of Hematology | Published : 2024
Abstract
Introduction Genomic alterations are common in multiple myeloma precursor stages, monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM). However, commonly used stratification systems do not include somatic alterations that play a role in the disease. To address this clinical need, we generated a comprehensive genomic map of MM and precursors by harmonizing and analyzing mostly WGS data from 1,030 patients. We used these data to define a simple MM-like score, that is able to discriminate which premalignant patients are at risk to progress. Methods We collected, enriched, and performed WGS of tumor ..
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