Journal article
Predicting type 2 diabetes and testosterone effects in high-risk Australian men: development and external validation of a 2-year risk model
KP Robledo, IC Marschner, M Grossmann, DJ Handelsman, BB Yeap, CA Allan, C Foote, WJ Inder, BGA Stuckey, D Jesudason, K Bracken, AC Keech, AJ Jenkins, V Gebski, M Jardine, G Wittert
European Journal of Endocrinology | OXFORD UNIV PRESS | Published : 2025
Abstract
Objective: We have shown that men aged 50 years+ at high risk of type 2 diabetes treated with testosterone together with a lifestyle program reduced the risk of type 2 diabetes at 2 years by 40% compared to a lifestyle program alone. To develop a personalized approach to treatment, we aimed to explore a prognostic model for incident type 2 diabetes at 2 years and investigate biomarkers predictive of the testosterone effect. Design: Model development in 783 men with impaired glucose tolerance but not type 2 diabetes from Testosterone for Prevention of Type 2 Diabetes; a multicenter, 2-year trial of Testosterone vs placebo. External validation performed in 236 men from the Examining Outcomes i..
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Awarded by Eli Lilly Australia
Funding Acknowledgements
Personal thanks: The authors are grateful to the T4DM study participants, as well as the excellent contributions of the study nurses: Glenda Fraser (ANZAC Research Institute and Concord Hospital), Jenny Healy (Austin Hospital), Helen Daniels and Chyn Soh (Fremantle Hospital and Fiona Stanley Hospital), Jody Sawyer (Princess Alexandra Hospital), Rosemary Cox and Fiona Cossey (The Queen Elizabeth Hospital), and Lee Mahoney (The Keogh Institute for Medical Research). This research was completed using data collected through the 45 and Up Study (www.saxinstitute.org.au). The 45 and Up Study is managed by the Sax Institute in collaboration with major partner Cancer Council NSW and partners the Heart Foundation and the NSW Ministry of Health. We are also grateful to the Centre for Health Record Linkage (CheReL; http://www.cherel.org.au/) for linkage of multiple sources of data from the 45 and Up Study, and the Secure Unified Research Environment (SURE) for provision of secure data access. We thank the many thousands of people participating in the 45 and Up Study.