Isomerized Aβ in the brains can distinguish the status of amyloidosis in the Alzheimer’s Disease continuum

Abstract

AbstractBackgroundThe extracellular amyloid plaques, one of the pathological hallmarks of Alzheimers Disease (AD), are frequently also observed in the cortex of cognitively unimpaired subjects or as co‐pathology in other neurodegenerative diseases. Progressive deposition of fibrillar amyloid‐β (Aβ) as amyloid plaques for two decades prior disease onset leads to extensive isomerization of Aβ N‐terminus. Quantifying the extent of isomerized Aβ can be provide insight into the different stages of amyloidosis in the brain.MethodsWe measured Aβ isoforms using mass spectrometry. We analysed postmortem brains (frontal cortex) from patient with AD (n = 59), Parkinson disease (n = 57) and age matched ..