Journal article
Adaptive functioning in children and young adults with monogenic neurodevelopmental disorders
EK Baker, M St John, R Braden, LD Morison, EJ Forbes, F Lelik, SJC Hearps, DJ Amor, AT Morgan
Developmental Medicine and Child Neurology | WILEY | Published : 2025
DOI: 10.1111/dmcn.16227
Abstract
Aim: To examine the adaptive behaviour profiles of children with monogenic neurodevelopmental disorders (NDDs) to determine whether syndrome-specific or transdiagnostic approaches provide a better understanding of the adaptive behavioural phenotypes of these NDDs. Method: This cross-sectional study included parents and caregivers of 243 (48% female) individuals (age range = 1–25 years; mean = 8 years 10 months, SD = 5 years 8 months) with genetically confirmed monogenic NDDs (CDK13, DYRK1A, FOXP2, KAT6A, KANSL1, SETBP1, BRPF1, and DDX3X). Parents and caregivers completed the Vineland Adaptive Behavior Scales, Third Edition to assess communication, daily living, socialization, and motor skill..
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Awarded by University of Melbourne
Funding Acknowledgements
Funding was provided by a National Health and Medical Research Council (NHMRC) Practitioner Fellowship no. 1105008 (ATM); an NHMRC Investigator Grant no. 1195955 (ATM); and NHMRC Centre of Research Excellence Translational Centre for Speech Disorders grants nos. 1116976 and 2015727 (ATM, DA). This work was supported by the Victorian Government's Operational Infrastructure Support Program. We also thank all the families for their contribution to this research. Open access publishing facilitated by The University of Melbourne, as part of the Wiley - The University of Melbourne agreement via the Council of Australian University Librarians.