Early-life protein-bound skin ceramides help predict the development of atopic dermatitis

CL Chang; E Berdyshev; E Milanzi; CJ Lodge; DJ Lopez; I Bronova; JJ Koplin; RL Peters; MLK Tang; SC Dharmage; MJ Abramson; J Hui; G Varigos; KP Perrett; A Sasi; JL Perret; JC Su; PD Robinson; DYM Leung; AJ Lowe

Journal article

Early-life protein-bound skin ceramides help predict the development of atopic dermatitis

CL Chang, E Berdyshev, E Milanzi, CJ Lodge, DJ Lopez, I Bronova, JJ Koplin, RL Peters, MLK Tang, SC Dharmage, MJ Abramson, J Hui, G Varigos, KP Perrett, A Sasi, JL Perret, JC Su, PD Robinson, DYM Leung, AJ Lowe

Journal of Allergy and Clinical Immunology | Published : 2025

DOI: 10.1016/j.jaci.2024.10.041

Open access

Abstract

Background: Skin lipids are crucial components of the skin barrier. Individuals with atopic dermatitis (AD or eczema) have a different skin lipid profile from those without. However, whether altered skin lipids precede and predict the subsequent risk of AD remained unclear, especially for different AD phenotypes. Objective: We sought to examine the relationship between skin lipids and subsequent AD and AD phenotypes in infants. Methods: Skin lipids from the forearms of 133 infants with family history of allergic disease were sampled using tape strips at age 6 weeks. Lipids were quantified using liquid chromatography-tandem mass spectrometry. AD by age 1 year was diagnosed using modified UK W..

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