Journal article
Therapy-Related Myeloid Neoplasms After [177Lu]Lu-PSMA Therapy in Patients with Metastatic Castration-Resistant Prostate Cancer: A Case Series
M Eifer, DEK Sutherland, I Goncalves, JP Buteau, L Au, AA Azad, L Emmett, G Kong, L Kostos, AS Ravi Kumar, EM Kwan, E Medhurst, S Sandhu, B Tran, AW Wyatt, MS Hofman
Journal of Nuclear Medicine | Published : 2025
Abstract
[177Lu]Lu-prostate-specific membrane antigen (PSMA) therapy has a favorable toxicity profile in patients with metastatic castration-resistant prostate cancer (mCRPC). Therapy-related myeloid neoplasm (t-MN) has been described after [177Lu]Lu-DOTATATE but has not, to our knowledge, yet been reported after [177Lu]Lu-PSMA. This case series describes 5 patients with mCRPC who developed t-MN after [177Lu]Lu-PSMA at our institution. Methods: In this single-center retrospective analysis, we reviewed all patients with mCRPC treated with [177Lu]Lu-PSMA. Patients who developed biopsy-proven t-MN during or after [177Lu]Lu-PSMA treatments are summarized with descriptive statistics. Results: From August ..
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