Journal article

Protective role of parenthood on age-related brain function in mid- to late-life

ER Orchard, S Chopra, LQR Ooi, P Chen, L An, SD Jamadar, BTT Yeo, HJV Rutherford, AJ Holmes

Proceedings of the National Academy of Sciences of the United States of America | Published : 2025

Open access

Abstract

The experience of human parenthood is near ubiquitous and can profoundly alter one’s body, mind, and environment. However, we know very little about the long-term neural effects of parenthood for parents themselves, or the implications of pregnancy and caregiving experience on the aging adult brain. Here, we investigate the link between the number of children parented and age on brain function in 19,964 females and 17,607 males from the UK Biobank. In both females and males, parenthood was positively correlated with functional connectivity, such that higher number of children parented was associated with higher connectivity, particularly within the somato/motor network. Critically, the spati..

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University of Melbourne Researchers