Evolving patterns of macrolide and fluoroquinolone resistance in Mycoplasma genitalium: an updated systematic review and meta-analysis

TP Chua; LA Vodstrcil; GL Murray; EL Plummer; JS Jensen; M Unemo; EPF Chow; N Low; DM Whiley; EL Sweeney; JS Hocking; JA Danielewski; SM Garland; CK Fairley; L Zhang; CS Bradshaw; DA Machalek

Journal article

Evolving patterns of macrolide and fluoroquinolone resistance in Mycoplasma genitalium: an updated systematic review and meta-analysis

TP Chua, LA Vodstrcil, GL Murray, EL Plummer, JS Jensen, M Unemo, EPF Chow, N Low, DM Whiley, EL Sweeney, JS Hocking, JA Danielewski, SM Garland, CK Fairley, L Zhang, CS Bradshaw, DA Machalek

The Lancet Microbe | Elsevier | Published : 2025

DOI: 10.1016/j.lanmic.2024.101047

Abstract

Background: Over the past 5 years, since publication of the initial review, studies have provided additional data on macrolide and fluoroquinolone resistance in Mycoplasma genitalium, including data from regions previously lacking this information. We aimed to provide contemporary estimates of macrolide and fluoroquinolone resistance in M genitalium to inform national, regional, and global treatment guidelines. Methods: This is an update of a previous systematic review and meta-analysis, which was performed up to Jan 7, 2019. In this update, we searched PubMed, Embase, and MEDLINE from Jan 1, 2018, to April 18, 2023, for published studies reporting macrolide, fluoroquinolone, or dual-class (..

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