Intelligence, educational attainment, and brain structure in those at familial high-risk for schizophrenia or bipolar disorder

SMC de Zwarte; RM Brouwer; I Agartz; M Alda; S Alonso-Lana; CE Bearden; A Bertolino; A Bonvino; E Bramon; EEL Buimer; W Cahn; EJ Canales-Rodríguez; DM Cannon; TD Cannon; X Caseras; J Castro-Fornieles; Q Chen; Y Chung; E De la Serna; C del Mar Bonnin; C Demro; A Di Giorgio; GE Doucet; MC Eker; S Erk; M Fatjó-Vilas; SC Fears; SF Foley; S Frangou; JM Fullerton; DC Glahn; VM Goghari; JM Goikolea; AL Goldman; AS Gonul; O Gruber; T Hajek; EL Hawkins; A Heinz; C Hidiroglu Ongun; MHJ Hillegers; J Houenou; HE Hulshoff Pol; CM Hultman; M Ingvar; V Johansson; EG Jönsson; F Kane; MJ Kempton; MMG Koenis; M Kopecek; B Krämer; SM Lawrie; RK Lenroot; M Marcelis; VS Mattay; C McDonald; A Meyer-Lindenberg; S Michielse; PB Mitchell; D Moreno; RM Murray; B Mwangi; L Nabulsi; J Newport; CA Olman; J van Os; BJ Overs; A Ozerdem; G Pergola; MM Picchioni; C Piguet; E Pomarol-Clotet; J Radua; IS Ramsay; A Richter; G Roberts; R Salvador; A Saricicek Aydogan; S Sarró; PR Schofield; EM Simsek; F Simsek; JC Soares; SR Sponheim; G Sugranyes; T Toulopoulou; G Tronchin; E Vieta; H Walter; DR Weinberger; HC Whalley; MJ Wu; N Yalin; OA Andreassen; CRK Ching; SI Thomopoulos; TGM van Erp; N Jahanshad; PM Thompson

Journal article

Intelligence, educational attainment, and brain structure in those at familial high-risk for schizophrenia or bipolar disorder

SMC de Zwarte, RM Brouwer, I Agartz, M Alda, S Alonso-Lana, CE Bearden, A Bertolino, A Bonvino, E Bramon, EEL Buimer, W Cahn, EJ Canales-Rodríguez, DM Cannon, TD Cannon, X Caseras, J Castro-Fornieles, Q Chen, Y Chung, E De la Serna, C del Mar Bonnin Show all

Human Brain Mapping | Published : 2022

DOI: 10.1002/hbm.25206

Open access

Abstract

First-degree relatives of patients diagnosed with schizophrenia (SZ-FDRs) show similar patterns of brain abnormalities and cognitive alterations to patients, albeit with smaller effect sizes. First-degree relatives of patients diagnosed with bipolar disorder (BD-FDRs) show divergent patterns; on average, intracranial volume is larger compared to controls, and findings on cognitive alterations in BD-FDRs are inconsistent. Here, we performed a meta-analysis of global and regional brain measures (cortical and subcortical), current IQ, and educational attainment in 5,795 individuals (1,103 SZ-FDRs, 867 BD-FDRs, 2,190 controls, 942 schizophrenia patients, 693 bipolar patients) from 36 schizophren..

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