Extended pharmacological thromboprophylaxis and clinically relevant venous thromboembolism after major abdominal and pelvic surgery: International, prospective, propensity score-weighted cohort study

A Sgrò; R Blanco-Colino; N Brindl; D Chaudhry; K Gressmann; RR Gujjuri; A Hilder; E Matey; IS Pereira; A Turňa; C Varghese; W Xu; S Brown; WA Cambridge; A Jaffer; I Jakaityte; SK Kamarajah; M Kawka; O Kouli; A Mergo; EC Mills; V Murray; S Ooi; AM Riad; SQ Shafi; I Trout; BM Biccard; A Docherty; J Martin; K El-Boghdadly; M Phull; R Mouton; A Bhangu; JC Glasbey; EM Harrison; N Smart; S Moug; T Pinkney; T Richards; I Dajti; M De Cillia; G Van Ramshorst; S Delibegovic; H Mughal; J Mihanovic; N Gouvas; P Kocian; V Levesen; J Kaupilla; D Merz; M Joos; A Ioannidis; G Nnaji; F Pata; G Pellino; A Gori; M Podda; C Riboni; E Moggia; E Fekaj; SO Senica; A Dauksa; J Psaila; F De Ruitjer; P Major; I Santos; MS Alves; J Simões; EA Bonci; A Pașca; A Novikova; B Kovačević; V Milosavljevic; B Tadic; J Kosir; SP Ajates; MEO Revilla; A Papadia; ML Gasparri; MK Aktas; BE Baki; MD Tepe; AU Mutlu; A Singal; J Osei-Bonsu; H Lacey; SW Chan; M Allison; K Duah-Asante; D Chen; N Ahmed; A Ejiz; C Takyi; M Mujeeb; N Ravikumar; M Khan; J Hayes; J McKenna; J Wang; N Essa

Journal article

Extended pharmacological thromboprophylaxis and clinically relevant venous thromboembolism after major abdominal and pelvic surgery: International, prospective, propensity score-weighted cohort study

A Sgrò, R Blanco-Colino, N Brindl, D Chaudhry, K Gressmann, RR Gujjuri, A Hilder, E Matey, IS Pereira, A Turňa, C Varghese, W Xu, S Brown, WA Cambridge, A Jaffer, I Jakaityte, SK Kamarajah, M Kawka, O Kouli, A Mergo Show all

British Journal of Surgery | Published : 2025

DOI: 10.1093/bjs/znaf005

Abstract

Background: There is low-certainty evidence on the impact of extended pharmacological prophylaxis on venous thromboembolism-associated morbidity and mortality. The aim of this study was to determine the efficacy and safety of extended prophylaxis after major abdominopelvic surgery for the prevention of clinically relevant venous thromboembolism after hospital discharge. Methods: CArdiovaSCulAr outcomes after major abDominal surgEry (CASCADE) was a prospective, international, cohort study into which consecutive adult patients undergoing major abdominopelvic surgery were enrolled (January-May 2022). Extended prophylaxis was considered at least 28 days of anticoagulant prescription after surger..

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