Journal article
Streptococcus pneumoniae serotype 33H: a novel serotype with frameshift mutations in the acetyltransferase gene wciG.
Sam Manna, Belinda D Ortika, Joel P Werren, Casey L Pell, Ilche Gjuroski, Stephanie W Lo, Jason Hinds, Odgerel Tundev, Eileen M Dunne, Bradford D Gessner, Fiona M Russell, E Kim Mulholland, Tuya Mungun, Claire von Mollendorf, Stephen D Bentley, Markus Hilty, Neil Ravenscroft, Catherine Satzke
Pneumonia (Nathan) | Published : 2025
Abstract
BACKGROUND: Streptococcus pneumoniae (the pneumococcus) is a leading cause of community-acquired pneumonia. Pneumococci are categorised into serotypes, based on the type of capsular polysaccharide produced, which has important implications for virulence, vaccine impact and global surveillance. Recently, we identified a novel serotype, which we named 33G, that is comprised of an O-acetylated hexasaccharide repeat unit. In this study, we report and describe variants of 33G, designated 33G-like, which we isolated from the nasopharynx of two adults hospitalised with pneumonia in Mongolia. METHODS: Serological comparison of 33G and 33G-like pneumococci were conducted by Quellung serotyping. Genet..
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Grants
Awarded by Robert Austrian Research Award in Pneumococcal Vaccinology
Awarded by Pfizer
Awarded by National Health and Medical Research Council (NHMRC) Centre of Research Excellence for Pneumococcal Disease Control in the Asia-Pacific