The Link Between Physical Function, β-Amyloid, and Cognitive Aging in Women

Abstract

This study aimed to examine associations between functional capacity (FC), brain β-amyloid (Aβ) burden, and longitudinal cognitive performance. Data from 89 cognitively normal women (70.0 ± 2.7 years) in the Women’s Healthy Ageing Project cohort were analyzed. FC was assessed using the timed up and go (TUG) test and the Aβ burden was quantified via a F-18 Florbetaben PET scan with Standardized Uptake Value Ratio (SUVR). Cognition was evaluated longitudinally using the Preclinical Alzheimer Cognitive Composite (PACC) over 3.9 ± 2.6 years. Multiple linear regression, mediation analysis, and linear mixed-effects models were applied. Baseline Aβ burden and years of education were associated with..