Ovarian cancer risk and survival according to tumor sex hormone receptor expression: An ovarian Cancer association consortium and ovarian tumor tissue analysis consortium pooled analysis

Z Fu; L Borho; SE Taylor; LE Kelemen; A DeFazio; PM Webb; M Köbel; NS Meagher; R Na; AC Antoniou; AH Brand; CJ Kennedy; N Nevins; PDP Pharoah; YB Shvetsov; SJ Winham; J Alsop; MW Beckmann; A Bolithon; J Boros; DDL Bowtell; JD Brenton; ME Carney; A Chudecka-Głaz; LS Cook; C Cybulski; PA Fasching; S Fereday; RT Fortner; MJ García; EL Goode; MT Goodman; J Gronwald; A Hartmann; BY Hernandez; E Høgdall; DG Huntsman; A Jensen; M Jimenez-Linan; JM Joseph; BY Karlan; E Kaznowska; SK Kjaer; T Kluz; JM Koziak; J Lester; TA Longacre; M Lycke; V McGuire; KB Moysich; RA Murphy; S Orsulic; SJ Ramus; C Rodríguez-Antona; JH Rothstein; S Samra; W Sieh; H Steed; K Sundfeldt; A Talhouk; J Uciński; C Wang; N Wentzensen; AS Whittemore; LR Wilkens; T Songer; MM Brooks; L Tang; F Modugno

Journal article

Ovarian cancer risk and survival according to tumor sex hormone receptor expression: An ovarian Cancer association consortium and ovarian tumor tissue analysis consortium pooled analysis

Z Fu, L Borho, SE Taylor, LE Kelemen, A DeFazio, PM Webb, M Köbel, NS Meagher, R Na, AC Antoniou, AH Brand, CJ Kennedy, N Nevins, PDP Pharoah, YB Shvetsov, SJ Winham, J Alsop, MW Beckmann, A Bolithon, J Boros Show all

Gynecologic Oncology | Published : 2025

DOI: 10.1016/j.ygyno.2025.05.013

Abstract

Objective: Many epithelial ovarian cancer (EOC) risk factors relate to sex hormones. The association between these factors and the expression of androgen receptor (AR), estrogen receptor-α (ER), and progesterone receptor (PR) in tumors is unknown. Method: We linked epidemiologic, AR/ER/PR tumor expression, and survival data from 19 studies in the Ovarian Cancer Association Consortium (OCAC; 4762 cases, 20,888 controls) and the Ovarian Tumor Tissue Analysis (OTTA) consortium (5737 cases). We estimated odds ratios (ORs) and 95 % confidence intervals (CIs) between hormonally-linked factors and tumor AR/ER/PR expression using polytomous logistic regression. We assessed survival by AR/ER/PR tumor..

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