Journal article

Association between risk-reducing surgeries and survival in young BRCA carriers with breast cancer: an international cohort study

E Blondeaux, A Sonnenblick, E Agostinetto, R Bas, HJ Kim, MA Franzoi, R Bernstein-Molho, S Linn, A Kwong, K Pogoda, J Balmana, A Smeets, J Bajpai, HCF Moore, AH Partridge, KA Phillips, A Toss, C Rousset-Jablonski, FA Peccatori, T Renaud Show all

Lancet Oncology | Published : 2025

DOI: 10.1016/S1470-2045(25)00152-4

Abstract

Background: Little evidence exists on the effect of risk-reducing surgeries in young BRCA carriers with a previous history of breast cancer. We investigated the association between risk-reducing mastectomy (RRM) or risk-reducing salpingo-oophorectomy (RRSO), or both procedures, with survival outcomes in a large global cohort of young BRCA carriers with previous breast cancer. Methods: The BRCA BCY Collaboration is an international, hospital-based, retrospective cohort study, conducted at 109 centres in five continents, including women harbouring germline BRCA1, BRCA2, or both, pathogenic or likely pathogenic variants and diagnosed with stage I–III invasive breast cancer at the age of 40 year..

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University of Melbourne Researchers

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Keywords

Women'S Health
32 Biomedical and Clinical Sciences
3211 Oncology and Carcinogenesis
3 Good Health and Well Being
Cancer
Prevention
Breast Cancer