Revealing early subchondral bone structural changes in osteoarthritis progression in a collagenase-induced mouse model using micro computed tomography

Abstract

INTRODUCTION The deployment of micro-computed tomography (microCT) enables quantitative morphometric analysis (QMA) to quantify morphological and structural changes caused by OA in mouse knee joint with excellent spatial resolution. Previous studies quantifying microstructural changes to subchondral tibiae in fortnightly intervals, report bone loss and trabecular thinning as early as two weeks post disease induction in mouse models. However, evidence suggests that the subchondral bone turnover may occur earlier than two weeks post disease induction in a mouse OA model. OBJECTIVE To reveal early bone microstructural changes associated with OA progression in a mouse model with a high temporal ..