Association of a Novel IgG3 Allele With Malaria in Children From the Sepik Region of Papua New Guinea

Abstract

Background. Susceptibility to malaria can be influenced by host genetic factors, including immune response genes. Antibodies against Plasmodium antigens are known to play an important role in protection from clinical disease. Polymorphisms in these antibodies may result in different functional properties that could provide protection from malaria. Methods. Immunoglobulin G1 (IgG1) and immunoglobulin G3 (IgG3) alleles and IgG3 hinge region were investigated by polymerase chain reaction and Sanger sequencing in a longitudinal cohort of children aged 1–3 years (N = 203) from the East Sepik region of Papua New Guinea. Linear regression was used to investigate associations between immunoglobulin ..